Crowdsourced protein design: the Adaptyv EGFR competition

April 17, 2025

At Adaptyv Bio we designed and ran an open competition for EGFR binders: about 159 participants submitted 1,800+ designs, and we put 601 of them through automated BLI to measure what actually bound. Hit-rates rose round over round as participants saw the previous round’s measurements and we wrote a few blog posts and a paper about it.